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Association details:
| Biomarker: | CES1 rs9921399T>C |
|---|---|
| Cancer: | Colorectal Cancer |
| Regimen: | FOLFIRI (5-fluorouracil + irinotecan + leucovorin calcium) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Combination of germline variations associated with survival of folinic acid, fluorouracil and irinotecan-treated metastatic colorectal cancer patients
Excerpt:
The association of 285 haplotype-tagging SNPs in 11 candidate genes and overall survival (OS) was tested in two cohorts totalizing 417 FOLFIRI-treated mCRC…In the combined cohort, CES1 rs9921399T>C was associated with prolonged OS (hazard ratio [HR] = 0.40)...
DOI:
10.2217/pgs-2019-0091
